Endocrine Abstracts

Erythropoietin (EPO) is an oxygen-regulated hormone promoting the differentiation of erythroid progenitor cells. Apart from hypoxia, few data is available about EPO release by secretagogues including hormones. This retrospective study evaluated serum EPO concentrations in serum leftovers from subjects routinely investigated with various endocrine disorders displaying: peripheral hypothyroidism or hyperthyroidism, acromegaly, endogenous Cushing’s syndrome or non secreting ...

Cortisol ([C]) biological activity depends on its free fraction diffusion into the intracellular compartment. The diagnosis of adrenal insufficiency requires investigations such as the synacthen test and studies in intensive care units suggest that free plasma [C] could provide a better indicator of efficient [C] than total plasma [C]. We undertook this study to compare various determinations of free [C] levels with regard to adrenal status evaluated on total plasma [C] after ...

The characteristics of adrenal involvement in Multiple Endocrine Neoplasia type 1 (MEN1) have been defined from studies involving a limited number of patients. We have assessed retrospectively the prevalence, characteristics and evolution of adrenal involvement from the French group for the study of endocrine tumours (GTE) registry, involving 688 patients with MEN1. In our series, adrenal tumours identified at abdominal imaging occurred in 130 patients (18.9%). The mean age of...